@font-face {
  font-family: 'DM Sans';
  font-style: normal;
  font-weight: 400;
  font-display: swap;
  src: url(/assets/font-0.ttf) format('truetype');
}
@font-face {
  font-family: 'DM Sans';
  font-style: normal;
  font-weight: 500;
  font-display: swap;
  src: url(/assets/font-1.ttf) format('truetype');
}
@font-face {
  font-family: 'DM Sans';
  font-style: normal;
  font-weight: 600;
  font-display: swap;
  src: url(/assets/font-2.ttf) format('truetype');
}
@font-face {
  font-family: 'DM Sans';
  font-style: normal;
  font-weight: 700;
  font-display: swap;
  src: url(/assets/font-3.ttf) format('truetype');
}
@font-face {
  font-family: 'Instrument Serif';
  font-style: italic;
  font-weight: 400;
  font-display: swap;
  src: url(/assets/font-4.ttf) format('truetype');
}
@font-face {
  font-family: 'Instrument Serif';
  font-style: normal;
  font-weight: 400;
  font-display: swap;
  src: url(/assets/font-5.ttf) format('truetype');
}

:root{--ink:#191d20;--paper:#f8f9f8;--muted:#536067;--line:#d4d9d9;--accent:#e6482b;font-family:'DM Sans',Arial,sans-serif;color:var(--ink);background:var(--paper);font-synthesis:none}*{box-sizing:border-box}html{scroll-behavior:smooth;scroll-padding-top:100px}body{margin:0}a{color:inherit;text-decoration:none}a:focus-visible,button:focus-visible,summary:focus-visible{outline:3px solid var(--accent);outline-offset:6px}.skip{position:absolute;left:1rem;top:-100px;z-index:100;background:white;padding:12px}.skip:focus{top:1rem}.site-header{height:104px;padding:0 5.2%;display:flex;align-items:center;justify-content:space-between;background:var(--paper);border-bottom:1px solid var(--line)}.wordmark{font-size:24px;letter-spacing:-1px;line-height:.93;font-weight:700}.wordmark span{display:block;font-size:12px;letter-spacing:5.4px;margin-top:9px;font-weight:500}nav{display:flex;gap:32px;font-size:14px;font-weight:500}nav a{padding:10px 0}nav a:hover{color:var(--accent)}.hero{min-height:730px;height:calc(100svh - 104px);max-height:1050px;position:relative;display:flex;flex-direction:column;justify-content:space-between;background:#151c23;color:white;padding:84px 5.2% 30px;overflow:hidden}.hero-content{z-index:1;max-width:1000px}.eyebrow{font-size:12px;line-height:1.5;text-transform:uppercase;letter-spacing:1.8px;font-weight:600;margin:0 0 32px}h1{font-size:clamp(56px,6.8vw,112px);line-height:1.02;font-weight:450;letter-spacing:-5px;margin:0 0 32px}h1 em{font-family:'Instrument Serif',Georgia,serif;font-style:italic;font-weight:400;letter-spacing:.01em;word-spacing:.06em;line-height:1.12}p{font-size:17px;line-height:1.75}.hero-intro{max-width:450px;color:#dfe4e5;font-size:19px;line-height:1.65}.button{display:inline-flex;align-items:center;justify-content:space-between;gap:36px;background:var(--accent);color:white;padding:18px 23px;margin-top:20px;font-size:14px;font-weight:600}.button:hover{background:#bb3820}.button span{font-size:24px;line-height:1}.hero-bottom{z-index:1;display:flex;justify-content:space-between;border-top:1px solid #ffffff50;padding-top:22px;font-size:12px;letter-spacing:1.5px;margin-top:60px}.section{padding:110px 5.2%;max-width:1800px;margin:auto}.intro{display:grid;grid-template-columns:1fr 2fr;gap:6%}h2{font-size:clamp(38px,4vw,64px);line-height:1.13;letter-spacing:-2px;font-weight:450;margin:0 0 28px}.lead{font-size:24px;line-height:1.5;max-width:760px}.intro p:not(.eyebrow){max-width:700px}.intro>div>p:last-child{color:var(--muted)}@media(max-width:700px){.site-header{height:90px;padding:0 6%}.wordmark{font-size:20px}.wordmark span{font-size:12px;letter-spacing:3.7px}nav{gap:15px;font-size:12px}nav a:last-child{display:none}.hero{height:auto;min-height:710px;padding:64px 6% 24px}h1{font-size:clamp(47px,9.4vw,68px);letter-spacing:-2px}.eyebrow{font-size:12px;letter-spacing:1.4px}.hero-intro{font-size:18px;max-width:330px}.hero-bottom{font-size:12px;line-height:1.7;gap:30px;flex-wrap:wrap}.hero-bottom span:last-child{display:none}.section{padding:72px 6%}.intro{grid-template-columns:1fr;gap:12px}.intro>.eyebrow{margin-bottom:12px}h2{letter-spacing:-1.5px}.lead{font-size:22px}}@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}}
/* Frontier Medicine editorial system */
.hero-image{position:absolute;inset:0;width:100%;height:105%;object-fit:cover;object-position:50% 45%;opacity:.8}.hero:after{content:"";position:absolute;inset:0;background:linear-gradient(90deg,rgba(5,12,18,.5),rgba(5,12,18,0) 85%),linear-gradient(0deg,rgba(5,12,18,.85),transparent 35%,rgba(5,12,18,.28))}.hero-bottom a{border-bottom:1px solid #ffffff60;padding-bottom:2px}.hero .eyebrow{color:#edf1f2}.definition{border-left:3px solid var(--accent);padding:6px 0 6px 28px;margin:42px 0 28px}.definition .eyebrow{color:var(--accent);display:block;margin-bottom:12px}.definition p{font-size:25px;line-height:1.55;margin:0;font-weight:500}.scope-note{font-size:14px!important;line-height:1.7!important}.horizons-wrap{background:#e9eeef;border-top:1px solid var(--line);border-bottom:1px solid var(--line)}.section-heading{display:grid;grid-template-columns:1.45fr 1fr;gap:8%;align-items:end;margin-bottom:60px}.section-heading h2{margin-bottom:0}.section-heading>p{max-width:450px;margin:0 0 4px;color:var(--muted)}h2 em{font-family:'Instrument Serif',Georgia,serif;font-weight:400;font-size:1.1em}.horizon-grid{display:grid;grid-template-columns:repeat(4,1fr);border-top:1px solid #b6c0c4}.horizon-grid article{padding:30px 28px 0 0;border-right:1px solid #b6c0c4;margin-top:28px;margin-right:28px;display:flex;flex-direction:column}.horizon-grid article:last-child{border:0;margin-right:0;padding-right:0}.index{font-family:'Instrument Serif',Georgia,serif;font-size:44px;color:#718188;line-height:1;margin-bottom:55px}h3{font-size:23px;letter-spacing:-.65px;line-height:1.3;font-weight:550;margin:0 0 16px}.horizon-grid p{font-size:16px;color:var(--muted);line-height:1.7;margin:0 0 28px}.text-link{font-size:14px;font-weight:600;display:inline-flex;gap:20px;align-items:baseline;line-height:1.6;text-decoration:underline;text-underline-offset:6px;text-decoration-color:#a3adb0}.text-link:hover{color:var(--accent);text-decoration-color:currentColor}.horizon-grid .text-link{margin-top:auto;font-size:13px;gap:12px}.environment{display:grid;grid-template-columns:1.06fr 1fr;gap:8%;align-items:start}.polar{margin:0;position:relative;align-self:stretch;min-height:740px;background:#b9cbd3}.polar img{width:100%;height:100%;object-fit:cover;object-position:52% 45%;position:absolute;inset:0}.polar figcaption{position:absolute;bottom:0;left:0;right:0;font-size:12px;letter-spacing:1.2px;padding:24px;background:linear-gradient(transparent,rgba(5,24,38,.8));color:white}.environment-copy{padding:28px 0}.environment-copy h2{font-size:clamp(36px,3.5vw,56px)}.environment-copy>p:not(.eyebrow){color:var(--muted)}.environment-copy .lead{color:var(--ink)!important}.principles{margin:30px 0}.principles>div{border-top:1px solid var(--line);padding:20px 0 4px}.principles h3{font-size:18px;letter-spacing:-.2px;margin-bottom:5px}.principles p{font-size:15px;line-height:1.65;color:var(--muted);margin:0 0 14px}.research-wrap{background:#192227;color:#eff2f3}.research-wrap .section-heading>p{color:#b9c5ca;font-size:16px}.research-wrap .eyebrow{color:#ff927a}.featured-papers{display:grid;grid-template-columns:repeat(3,1fr);gap:24px}.feature-paper{border-top:2px solid #ff7457;padding:26px 24px 26px 0;display:flex;flex-direction:column}.paper-meta{font-size:12px;letter-spacing:1px;text-transform:uppercase;color:#bcc9ce;line-height:1.6;display:flex;justify-content:space-between;gap:12px;margin-bottom:28px}.feature-paper h3{font-size:25px;line-height:1.35;font-weight:450;letter-spacing:-.6px}.paper-copy h3 a:hover{color:#ff927a}.feature-paper p,.paper-row p{font-size:16px;line-height:1.7;color:#b9c5ca}.citation{font-size:12px;line-height:1.75;color:#b9c5ca;margin-top:25px}.citation a{text-decoration:underline;text-underline-offset:3px}.paper-link{display:flex;align-items:center;justify-content:space-between;border-top:1px solid #50616a;padding-top:18px;font-size:14px;margin-top:28px;line-height:1.5}.paper-link:hover{color:#ff927a}.feature-paper 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h2{font-size:clamp(38px,4vw,60px)}.question-list>div{display:grid;grid-template-columns:32px 1fr;gap:0 20px;border-top:1px solid var(--line);padding:26px 0}.question-list>div:first-child{padding-top:0;border:0}.question-list span{font-size:13px;color:var(--accent);padding-top:4px}.question-list h3{font-size:24px;font-weight:450;letter-spacing:-.5px}.question-list p{grid-column:2;font-size:16px;line-height:1.7;color:var(--muted);margin:0}.about-wrap{background:#dee7e9}.about{display:grid;grid-template-columns:1fr 1.3fr;gap:8%}.about .lead{margin-top:0}.about p:not(.lead):not(.eyebrow){color:#46565e}.about-small{font-size:14px;margin-top:32px}.site-footer{padding:60px 5.2% 30px;background:var(--paper)}.footer-top{display:flex;justify-content:space-between;align-items:center;padding-bottom:42px;border-bottom:1px solid var(--line)}.footer-bottom{display:grid;grid-template-columns:1fr 1fr;gap:10%;margin-top:22px}.footer-bottom p{font-size:13px;line-height:1.75;color:var(--muted);max-width:630px}details{border-top:1px solid var(--line);padding-top:18px;margin-top:26px}summary{font-size:13px;cursor:pointer;width:fit-content;line-height:1.8}details p{font-size:13px;max-width:850px;line-height:1.75;color:var(--muted)}details a{text-decoration:underline;text-underline-offset:3px}.domains{padding-top:0}.domains-header{display:grid;grid-template-columns:1fr 2fr;gap:6%;padding-top:70px;border-top:1px solid var(--line)}.domains-header h2{font-size:40px}.domain-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:32px;margin-top:24px}.domain-grid article{border-top:2px solid var(--ink);padding-top:25px}.domain-grid p{font-size:16px;line-height:1.7;color:var(--muted)}.domain-grid h3{font-size:24px}.domain-note{font-size:13px;color:var(--muted);margin-top:24px;max-width:900px}
@media(min-width:1800px){.site-header,.site-footer{padding-left:max(5.2%,calc((100vw - 1612px)/2));padding-right:max(5.2%,calc((100vw - 1612px)/2))}}@media(max-width:1100px){.horizon-grid{grid-template-columns:repeat(2,1fr);row-gap:45px}.horizon-grid article:nth-child(2){border:0;padding-right:0;margin-right:0}.environment{gap:5%}.polar{min-height:800px}.paper-row{grid-template-columns:145px 1fr;gap:22px}.paper-row .paper-link{grid-column:2;max-width:140px}.domain-grid{grid-template-columns:repeat(2,1fr)}.feature-paper h3{font-size:22px}.featured-papers{gap:20px}}@media(max-width:700px){.hero-image{object-position:62% 50%;opacity:.8}.hero:after{background:linear-gradient(180deg,rgba(3,12,18,.55),rgba(3,12,18,.1) 70%,rgba(3,12,18,.65))}.hero-bottom a{display:none}.definition{padding-left:22px;margin-top:30px}.definition p{font-size:22px}.section-heading{grid-template-columns:1fr;gap:24px;margin-bottom:35px}.section-heading>p{font-size:16px}.horizon-grid{grid-template-columns:1fr;gap:0}.horizon-grid article{border-right:0;border-bottom:1px solid #b6c0c4;padding:0 0 30px;margin:28px 0 0;display:grid;grid-template-columns:40px 1fr;gap:0 12px}.horizon-grid article:nth-child(2){border-bottom:1px solid #b6c0c4;padding-bottom:30px}.index{font-size:30px;margin:0;grid-row:1/4}.horizon-grid h3{font-size:25px}.horizon-grid p{margin-bottom:18px}.horizon-grid .text-link{grid-column:2;font-size:14px}.environment{grid-template-columns:minmax(0,1fr)}.polar{min-width:0;width:100%;min-height:440px;aspect-ratio:4/5}.environment-copy{padding:42px 0 0}.featured-papers{grid-template-columns:1fr;gap:10px}.feature-paper{padding:24px 0 30px}.feature-paper h3{font-size:26px}.paper-meta{margin-bottom:20px}.library-heading{display:block;margin-top:40px}.library-heading h3{margin-bottom:5px}.library-heading p{margin:0}.paper-row{grid-template-columns:1fr;gap:10px;padding:30px 0}.paper-row .paper-meta{display:flex;margin:0}.paper-row .paper-meta span{margin:0}.paper-row h3{font-size:23px}.paper-row .paper-link{grid-column:1;margin-top:5px}.questions,.about{grid-template-columns:1fr;gap:24px}.questions h2{margin-bottom:12px}.question-list h3{font-size:22px}.question-list>div{grid-template-columns:24px 1fr;gap:0 15px}.footer-bottom{grid-template-columns:1fr;gap:0}.footer-top{gap:35px}.footer-top .text-link{font-size:13px}.domains-header{grid-template-columns:1fr;gap:0;padding-top:35px}.domains-header h2{font-size:36px}.domain-grid{grid-template-columns:1fr;gap:15px}.domain-grid article{padding-top:20px}.domain-grid h3{font-size:25px}.domains{padding-top:0}}@media(prefers-reduced-motion:no-preference){a{transition:color .18s,background .18s}}
@media(max-width:700px){.site-header nav a:nth-child(1),.site-header nav a:nth-child(3),.site-header nav a:nth-child(5){display:none}.site-header nav{gap:22px;font-size:14px}}

.longitudinal-horizon{display:grid;grid-template-columns:1fr 1fr;gap:8%;border-top:1px solid #b6c0c4;margin-top:64px;padding-top:42px}.longitudinal-horizon h3{font-size:30px;line-height:1.25}.longitudinal-horizon p:not(.eyebrow){font-size:16px;color:var(--muted);max-width:620px}.longitudinal-horizon .eyebrow{margin-bottom:22px}.longitudinal-horizon .text-link{margin-top:12px}@media(max-width:700px){.longitudinal-horizon{grid-template-columns:1fr;gap:22px;margin-top:36px;padding-top:32px}.longitudinal-horizon h3{font-size:27px}}